There are many surprising ways in which issues with the water supply have altered the path of New York City’s history. As the population exploded during the eighteenth and early nineteenth century, the water supply and its quality shaped the growth of urban development. Poor water supply systems created a constant threat of water-born diseases for early Manhattanites — in particular, yellow fever. While Lower Manhattan (specifically Wall Street) has been America’s center of finance for over two centuries, for brief periods in the nineteenth century Greenwich Village housed bankers and businessmen (as well as many other New Yorkers) seeking to escape periodically vicious outbreaks of yellow fever.
After a particularly deadly outbreak of yellow fever in 1798, Aaron Burr along with his associates petitioned to create a private company that would supply the city with water from fresher and “safer” sources. The Manhattan Company was thereby created. However, it was actually Burr’s intention to use the company as a front in order to establish a bank — an immensely complicated undertaking in that era. A brief annotation to the Manhattan Company’s charter allowed for excess stock to be used “in the purchase of public stock or in any other monied transactions or operations not inconsistent with the Constitution and laws of the United States.” Unfortunately, since the company’s main goal was to establish a bank, The Manhattan Company was slow and inept at creating a systematic and safe water supply for the city, and the outbreaks of yellow fever persisted.
The Bank of New York — the oldest bank in the United States and founded by Alexander Hamilton — started a trend of banks moving temporarily northward to escape yellow fever, galvanized by a clerk at the bank’s Wall Street headquarters contracting the disease during the 1798 outbreak. Subsequent epidemics in 1803, 1805, and 1822 pushed other banks, such as Bank of the Manhattan Company and Phenix Bank, to the same block of land inhabited by the temporary sanctuary of the Bank of New York. This cluster of businesses resulted in the naming of the strip “Bank Street,” which is still present today in the West Village.

The Bank of New York, watercolor by John William Hill, The Phelps Stokes Collection, New York Public Library
1822 marked the last great yellow fever outbreak in lower Manhattan. One 1823 report of the epidemic by Dr. Peter S. Townsend recalled “the timely and almost total abandonment of all that part of the city south of Fulton-street…” One citizen described how “[f]rom daybreak till night, one line of carts, containing boxes, merchandize and effects, were seen moving towards Greenwich Village and the upper parts of the city.” However, business was soon as bustling as before in their temporary Greenwich Village retreat:
Within a few days thereafter, the Custom House, the Post Office, the Banks, the Insurance Offices, and the printers of Newspapers located themselves in the village… where they were free from the impending danger, and these places almost instantaneously became the seat of the immense business usually carried on, in this great metropolis.

Excerpt from James Hardie’s “An account of the yellow fever, which occurred in the city of New-York, in the year 1822”
The rustic appeal of Greenwich Village would not last much longer. By 1837, construction of the Croton Aqueduct would begin: soon the city would have an abundant and clean water supply and the yellow fever outbreaks would subside. Greenwich Village would thereafter become home to factories and tenements — a far cry from its bucolic beginnings. However, before this development, the village provided sanctuary to the citizens of lower Manhattan, and allowed New York bankers to continue business as usual.
I think its interesting how you touch on the unfortunate way business interests acted as an impediment to public health issues, but I am also curious about how the residents of Greenwich Village felt about the influx of people and commerce during the outbreaks. Did they welcome the business or were they upset with the incursion on their village? Were they afraid of disease spreading? Were there many people living in Greenwich Village at the time? Just some thoughts. Its a fascinating topic.
I think what is so incredible about this particular era in Greenwich Village history is how few residents it actually had! Most of the Village (as I understand) was owned by a handful of farmers, and that is all. It would be interesting to look up the census records of the time and see who considered the Village their full-time home.
Regardless, it is an interesting query and I hope my research will uncover some information on your question.
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